1. substance - noun
· the real physical matter of which a person or thing consists; "DNA is the substance of our genes"
2. substance - noun
· the choicest or most essential or most vital part of some idea or experience; "the gist of the prosecutor's argument"; "the heart and soul of the Republican Party"; "the nub of the story"
3. substance - noun
· the idea that is intended; "What is the meaning of this proverb?"
4. substance - noun
· material of a particular kind or constitution; "the immune response recognizes invading substances"
5. substance - noun
· considerable capital (wealth or income); "he is a man of means"
6. substance - noun
· what a communication that is about something is about
7. substance - noun
· the property of holding together and retaining its shape; "wool has more body than rayon"; "when the dough has enough consistency it is ready to bake"
8. substance - noun
· a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
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